DENOSUMAB (den oh sue mab) slows bone breakdown. In this article well discuss the uses, side effects, safety precautions, and other important information about Prolia. It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. you can take. Theyll do this with certain tests, such as a bone scan or ultrasound. But its believed that these side effects are rare. Call your doctor at once if you have: new or unusual pain in your thigh, hip, or groin; severe pain in your joints, muscles, or bones; skin problems such as dryness, peeling, redness, itching, blisters, bumps, oozing, or crusting; or. You should also talk with them if you have any serious side effects during Prolia treatment. A special MedGuide will be given to you before each treatment. It is created by eHealthMe based on reports of 8,432 people who take Prolia and Calcium from the FDA, and is updated regularly. (2021). As mentioned above, Prolia contains the active drug denosumab. Nonmetastatic means the cancer hasnt spread to other areas of the body. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Prolia can also cause low calcium levels. * Sex and gender exist on spectrums. In addition, your doctor will most likely recommend that you take calcium and vitamin D supplements while taking bisphosphonates, since vitamin D helps your body to absorb calcium. This medicine is only given in a clinic, doctor's office, or other health care setting and will not be stored at home. WebDrug interactions are reported among people who take Prolia and Calcium. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. Both are prescription medicines. Every 6 months youll get another dose of Prolia. Talk with your doctor about which other treatments are better choices for you. Tell your doctor if youd like to know more about these drugs. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. If you dont understand something related to your condition or treatment, ask your doctor to explain it to you. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. Its recommended that you take 400 international units of vitamin D and 1,000 milligrams (mg) of calcium with Prolia. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. If you plan to drink alcohol while using Prolia, ask your doctor how much is safe to drink. See additional information. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Weakness and tingling can also occur. This drug may not be the right treatment for your condition if you have certain medical conditions or other factors that affect your health. Some people who take Prolia develop severe bone, joint, or muscle pain. Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. For more information about how these medications compare with each other, ask your doctor. If youre concerned about side effects with Prolia, talk with your doctor. They do this by slowing the loss of minerals such as calcium from your bones. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. If you miss a dose of Prolia, you should receive your injection as soon as you can. Call your doctor right away if you have an allergic reaction to Prolia. This list doesnt include all possible mild side effects of the drug. Specifically, Prolia is a monoclonal antibody (a lab-made protein). It could harm the unborn baby or cause birth defects. And in my mind, that's no different than scheduling a visit to the dentist twice a year. Thyroid or parathyroid surgery. A few examples of bisphosphonates include: If youd like to know more about using a bisphosphonate for your condition, talk with your doctor. To learn more about this side effect, see Side effect specifics below. The drug stays in your system and continues to slow bone breakdown over this period of time. What Health Changes Should You Expect Postmenopause? Although its rare, your doctor may give you the option to self-inject Prolia at home. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. Drug interactions are reported among people who take Prolia and Calcium. Your doctor may suggest limiting foods that are high in trans fats, such as fried foods. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. * Symptoms can include: flushing (temporary warmth, redness, or deepening of skin color), swelling under your skin, typically in your lips, eyelids, feet, or hands, swelling of your mouth, tongue, or throat, which can make it hard to breathe. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. (Biosimilars are like generic drugs. Find out which foods can help. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture Prolia comes as a solution thats given as an injection under your skin. eHealthMe is studying from 146,783 Calcium users for its effectiveness, alternative drugs and more. Serious side effects of Prolia that have been reported include: For most people, Prolias side effects are mild and go away after a few days to a few weeks. Find out why people need calcium, which foods provide it, and what happens if they consume. The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. These are serious. What should I know about Prolia vs. Zometa? Osteoporosis is a condition that causes your bones to become thin and weak. If your pain becomes severe, your doctor may recommend other treatment options to replace Prolia. This increases your risk for bone fractures. You may be interested in learning how Prolia compares to the medication Fosamax. Denosumab is contraindicated in women with hypocalcaemia. However, drinking too much alcohol may raise your risk of falling. Some people have developed unusual fractures in their thigh bone. Be sure to talk with your doctor about your health history before you take Prolia. Calcium supplements may help support bone and teeth health. Youll receive Prolia doses from a healthcare professional. Your risk may also be higher if you: Stopping Prolia treatment can also increase your risk for bone fractures. Another common osteoporosis medication is denosumab (Prolia, Xgeva). Heres a short list of some of the mild side effects that Prolia can cause. You should talk with your doctor if you develop any mild side effects that concern you. Stopping Prolia doesnt cause withdrawal symptoms. If you are a healthcare professional, click "I Agree" to continue. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. Tell them if you have any scheduled dental work coming up. Breastfeeding. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. What are some frequently asked questions about Prolia? Tell your doctor if you become pregnant. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. These articles might help: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. It comes as a liquid solution thats given as an injection. And theyll recommend if its the best option for your condition. Tingling wasnt specifically reported as a side effect of Prolia in clinical trials. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.). They can explain the risks and benefits of this drug. They can also tell you about other treatment options available for osteoporosis and bone loss prevention. Factors to consider include those in the list below. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. If youre breastfeeding, you should not receive Prolia. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. Prolia contains the active drug denosumab, and Reclast contains the active drug zoledronic acid. If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. Talk with your doctor if youd like to know about taking generic denosumab. Follow your doctor's instructions. Kidney problems. Bring someone with you to your appointment if doing so will help you feel more comfortable. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. If you have a male* sexual partner, they should use birth control during this time as well. Let your doctor know if you have questions about which drug is recommended for you. Talk with your doctor about your health history and discuss your risks with Prolia treatment. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. But tingling may be a symptom of side effects such as sciatica and hypocalcemia. Continue reading, While there are no known drug interactions between Prolia (generic name: denosumab) and alcohol, but you should check with your doctor first before you drink. Heres some information on pregnancy, breastfeeding, and Prolia use. Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. Do not treat yourself. Youll likely receive Prolia long term if you and your doctor decide that the drug is effective and safe for you. Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Check with your doctor if you have more questions about these drugs. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. Last updated on Feb 8, 2023. Not getting enough calcium in your diet can lead to fragile, brittle bones that are more prone to fractures and disease. You should not breastfeed while using this medicine. Prolia contains the active drug denosumab, while Tymlos contains the active drug abaloparatide. American Dental Association (ADA) recommendations say that tooth extractions are allowable if needed during Prolia treatment, if both you and your dentist agree. Do not use denosumab if you are pregnant. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. Prolia may cause serious side effects. Having dental procedures, including tooth extractions, during Prolia treatment may increase your risk of dental side effects. So be sure to tell your doctor about all your health conditions before taking Prolia. Vertigo (dizziness) was reported in some people who received Prolia for osteoporosis, but this was a less common side effect. You should receive your missed injection as soon as possible. Brush and floss your teeth regularly. What should be considered before taking Prolia? For Xgeva, talk to your pediatrician regarding the use of this medicine in children. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. The two most common forms of arthritis are osteoarthritis and rheumatoid arthritis (RA). In addition to treating osteoporosis, which is described just above, Prolia also has other uses. Try to avoid being around people who are sick. All information is observation-only. in your skin, lower stomach area (abdomen), bladder, or ear may happen. Now i am worried that i've been taking K2 which also takes calcium from the blood to the bones. They can give you more details about this possible side effect and suggest ways to manage it. Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or. Rare, long-term side effects of Prolia include fractures of the spine or femur (thighbone). They may also have you see your dentist. If youve been diagnosed with osteoporosis, your doctor may discuss Prolia with you. You might be interested in seeing how Prolia and the drug Boniva compare. Special care may be needed. All rights reserved. Its given to adults who are at high risk for bone fractures. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving this medicine. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Do not stop, skip or delay taking Prolia without first talking with your doctor. Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, 11 ways to increase bone density naturally, 14 of the best calcium supplements in 2023. An allergic reaction is possible after using Prolia. (A low blood calcium level is a possible side effect of Prolia.). Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. You may also want to do some research on your own. The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. But weight gain may be a symptom of a side effect called peripheral edema. You should also take calcium and vitamin D supplements while being Prolia is an injection prescribed for certain adults with osteoporosis, which Do any of yall know? (2022). Your side effects from Prolia may also vary depending on your gender. Prolia may be used off-label for RA, if you have a high risk for bone fractures. But nausea may be a symptom of side effects such as vertigo or constipation. If your levels are high, theyll typically recommend lifestyle changes and medication. The study uses data from the FDA. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines Talk with your doctor before starting Prolia treatment. Copyright 1996-2023 Cerner Multum, Inc. Personalize this study to your gender and age, Arthrotec and Alanine Aminotransferase Increased, Capecitabine and Lumigan drug interaction, Cyramza and Gastrointestinal Stoma Necrosis, Simponi Aria and Pennsaid drug interaction, Docetaxel and Infection In An Immunocompromised Host, Ketorolac Tromethamine and Bladder Obstruction, Roxicodone and Caspofungin Acetate drug interaction, Ginkgo and Nitrofurantoin drug interaction. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. We comply with the HONcode standard for trustworthy health information. While you are using Prolia, you should not receive Xgeva, another brand of denosumab. Xgeva is also used to treat giant cell tumor of the bone. They may want to check for other causes. Allergic reaction. Also describe any vitamins, herbs, or supplements you use. Although very rare, Prolia can cause serious dental problems and jaw-related side effects. But Prolia is given once every 6 months by a healthcare professional. Your doctor can also advise you on symptoms of low calcium to look for. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Common side effects of Prolia can vary depending on which condition the drug is being used to treat. They may be able to help you identify the cause. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. But certain choices and habits accelerate the process. They may give you tips on managing a body weight thats healthy for you. (A placebo is a treatment with no active drug.). Prolia can also increase this risk. They include bone pain, back pain, and a higher risk of certain infections. Prolia is used in adults to treat osteoporosis or bone loss in people who: who cannot use another osteoporosis medicine or these medicines did not work well. We do not endorse non-Cleveland Clinic products or services. If you have osteoporosis or bone loss, your doctor may discuss Prolia as a treatment option. Pay special attention to your dental hygiene. Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. Prolia may cause serious side effects. But some females* who received Prolia for osteoporosis after menopause had to stop Prolia treatment due to back pain. Side effects are possible with Prolia use, but in most cases they go away after a while. In fact, bone breakdown is higher in the first several months after you stop Prolia. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. Boniva contains the active drug ibandronate, but Prolia contains the active drug denosumab. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. Results may vary. This may help to protect healthy cells from damage. A healthcare provider will give you this injection in a hospital or clinic. * Sex and gender exist on spectrums. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. If you have a low calcium level, you should not take Prolia. Coral calcium is also used in maxillofacial surgery and bone grafting. There is a potential for serious side effects to an unborn child. There arent any reported interactions between Prolia and alcohol. Prolia improves bone mass and increases bone mineral density. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. It may not cover all possible information. Your risk for some health conditions increases when you are postmenopausal. Drug class: Miscellaneous bone resorption inhibitors. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. for breast cancer that has not spread to other parts of the body. See what this means for you in the chart below. Keep out of the reach of children and pets. If you have bothersome or severe side effects or other problems while taking Prolia and need to stop the medication, your doctor will monitor your bone mineral density. You may want to know how Prolia compares to the medication Tymlos. Copyright 2023 Elsevier Inc. All Rights Reserved. Please see Prolia full A severe jawbone problem called osteonecrosis has rarely been reported with Prolia. Patients should not stop Prolia treatment without first consulting your Do not shake the prefilled syringe. It can have some side effects, but these may depend on who uses it. Also, its important to brush and floss your teeth regularly while youre using Prolia. Learn about the different options, including the benefits of each and any potential side, A FRAX score can help predict the risk of fractures in people with osteoporosis. You can learn more about how we ensure our content is accurate and current by reading our. Since different people Drug class: miscellaneous bone resorption inhibitors. Prolia has active ingredients of denosumab. Some items may interact with your medicine. They can recommend a treatment option other than Prolia. Problem absorbing minerals. Use of the terms female and male in this article refers to sex assigned at birth. Before your appointment, write down questions, such as: How will Prolia affect my body, mood, or lifestyle? Although both drugs are approved to treat similar conditions, they work in different ways. You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. WebAdults ages 19 through 50 should not get more than 2,500 mg calcium total per day (including food and supplements). If you have low calcium levels, you should not take Prolia. If youd like to know more about the differences and similarities of Prolia and Evenity, see this comparison. Use of the term female in this article refers to sex assigned at birth. Yoga for Osteoporosis: 5 Beneficial Poses, Diet and Osteoporosis: Nutrients, Diet Tips, and More. Ask your doctor about the pros and cons of using Prolia. Theyll also usually treat the hypocalcemia right away. Call your doctor for medical advice about side effects. Vitamin D The body needs vitamin D to absorb calcium. These can include tingling or numbness in the hands, feet, and face. If your doctor says this is safe for you, youll be shown how to inject the medication. You may report side effects to FDA at 1-800-FDA-1088. Do not share this medicine with others. Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct But before taking Prolia, be sure to tell your doctor about all medications you take (including prescription and over-the-counter types). Use of the term male in this article refers to sex assigned at birth. Doing so will help to prevent dental problems. If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. Youll likely have questions about your condition and treatment choices. You should also talk with your doctor if you have nausea during treatment. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. Do not reuse a needle or syringe. With osteoporosis, your bones become porous, meaning there are large holes within your bone tissue. (Vitamin D helps your body absorb calcium.) People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. Below are answers to some commonly asked questions about Prolia. Other side effects may continue for as long as you receive the medication, but they can often be relieved with other treatments. It is often used in osteoporosis. Also tell them if you smoke, drink alcohol, or use illegal drugs. For instance, if you have a health condition that causes excess calcium in These factors include what your insurance plan covers. Heres a sample meal plan thats packed with nutritious foods just for. We avoid using tertiary references. Call your doctor for instructions if you miss a dose or miss an appointment for your Prolia injection. This could include having: Before taking Prolia, share your dental history with your doctor. They can help answer any questions you have about side effects from taking the drug. The drug may also be used off-label for osteopenia, but usually, you dont need medications for osteopenia. Medically reviewed by Sanjai Sinha, MD. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. Bone pain from Prolia may be most noticeable in your arms and legs. * Approximation only. Some side effects of Prolia may go away on their own within a few days or weeks after starting treatment. Other studies have examined the risk of damage to jaw tissue with the use of bisphosphonates, one type of medication commonly used to treat osteoporosis. They might also recommend physical therapy, massage therapy, or using a heating pad. For example, in the studies, people taking Prolia for up to 8 years didnt have significant side effects compared with people taking a placebo. If youre concerned about hair loss with Prolia, talk with your doctor. Terms of Use. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Before beginning treatment with Prolia, ask your doctor about the benefits and risks of the drug. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed. It is often used in osteoporosis. What should I know about Prolia vs. Reclast? No, Prolia isnt a bisphosphonate. With these reports, it wasnt known whether Prolia or something else (such as a different medication) caused the hair loss. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. Do not take this medicine with any of the following medications: This medicine may also interact with the following medications: This list may not describe all possible interactions.
why did julia st john leave the brittas empire,